Heme oxygenase-1: an important therapeutic target for protecting against myocardial ischemia and reperfusion injury.
نویسندگان
چکیده
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منابع مشابه
Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice.
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Ischemia/reperfusion injury is a reaction occurring after successful treatment of an acute myocardial infarction or in the setting of solid organ transplantation. After successful reperfusion of a previously occluded vessel or a transplanted organ, an additional loss of otherwise vital cells may occur, the so-called lethal ischemia-reperfusion injury. This lethal reperfusion injury is based on ...
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OBJECTIVES We assessed the hypothesis that overexpression of the antioxidant enzyme heme oxygenase (HO)-1 may protect against chronic recurrent ischemia/reperfusion injury. BACKGROUND Multiple and recurring episodes of myocardial ischemia can result in significant myocardial damage, including myocyte death, fibrosis, and wall thinning, leading to impaired ventricular function and cardiac fail...
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Ischemia and reperfusion represent major mechanisms of tissue injury and organ failure. The timing of administration and the duration of action limit current treatment approaches using pharmacological agents. In this study, we have successfully developed a preemptive strategy for tissue protection using an adenoassociated vector system containing erythropoietin hypoxia response elements for isc...
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ورودعنوان ژورنال:
- International journal of cardiology
دوره 167 2 شماره
صفحات -
تاریخ انتشار 2013